Review Session Details
- Understand general mechanism for enzyme catalysis (i.e. catalysis via induced fit, covalent catalysis, acid-base catalysis, catalysis by approximation and metal-ion catalysis)
- Using specific case studies, learn to identify which type of catalysis is being used by enzyme
- Learn how cofactors and coenzymes are involved in enzyme catalysis (with specific examples)
- Understand how allosteric binding can lead to feedback activation or inhibition (will use Aspartate transcarbamoylase (ATCase) to understand concept)
- Learn other forms of enzyme regulations such as: isozymes, reversible covalent modification, proteolytic cleavage and transcriptional control
- Learn how various types of reversible inhibitors can affect Michaelis-Menten parameters (Km and Vamx)
- Graphically understand how to determine which type of reversible inhibitor is present using a Line-weaver Burke plot
- Learn about the different types of irreversible inhibitors
